"The difference between approaching themes in art and in genre is a matter of comfort. And I think that it’s a matter of intellect. For example, what happens in The Fly would be very hard to take in a normal drama. Basically an attractive guy meets an attractive girl and then contracts a terrible wasting disease and the girl watches as he deteriorates and ultimately she helps to kill him. That’s really the plot of The Fly on an emotional level and that would be very hard to take if it were just a realistic drama. But when it’s a sci-fi horror mix, it sort of allows the audience to have some distance and they still feel the emotional impact of those things, but it gives them a little bit of safety, you know? But in terms of a movie like Naked Lunch or Crash, it’s just a question of what people are used to and what they expect from a movie. And when they’re not getting the structure that they’re familiar with, or an aesthetic approach that they understand, then there is a distance there but it’s not a good distance. It’s off-putting to them. So at that point the appeal is to a much narrower audience that can understand you and engage with the movie that you’ve made."